MirGeneDB 2.1
MirGeneDB ID

Hsa-Mir-221-P2a

Family name MIR-221 (all species)
Seed CCUGGCA
Species Human (Homo sapiens)
MiRBase ID hsa-mir-221
Paralogues Hsa-Mir-221-P1a 
Orthologues Aca-Mir-221-P2a  Ami-Mir-221-P2a  Bta-Mir-221-P2a  Cfa-Mir-221-P2a  Cli-Mir-221-P2a  Cmi-Mir-221-P2a  Cpi-Mir-221-P2a  Cpo-Mir-221-P2a  Dno-Mir-221-P2a  Dre-Mir-221-P2a1  Dre-Mir-221-P2a2  Ete-Mir-221-P2a  Gga-Mir-221-P2a  Gja-Mir-221-P2a  Gmo-Mir-221-P2a1  Gmo-Mir-221-P2a2  Lch-Mir-221-P2a  Loc-Mir-221-P2a  Mal-Mir-221-P2a1  Mal-Mir-221-P2a2  Mdo-Mir-221-P2a  Mml-Mir-221-P2a  Mmu-Mir-221-P2a  Mun-Mir-221-P2a  Oan-Mir-221-P2a  Ocu-Mir-221-P2a  Pbv-Mir-221-P2a  Rno-Mir-221-P2a  Sha-Mir-221-P2a  Spt-Mir-221-P2a  Sto-Mir-221-P2a  Tgu-Mir-221-P2a  Tni-Mir-221-P2a1  Xla-Mir-221-P2a3  Xla-Mir-221-P2a4  Xtr-Mir-221-P2a 
Node of Origin (locus) Gnathostomata
Node of Origin (family) Vertebrata
Genome context
(hg38)		 chrX: 45746180-45746242 [-] UCSC Ensembl
Clustered miRNAs
(< 50kb from Mir-221-P2a)		 Mir-221-P2a chrX: 45746180-45746242 [-] UCSC Ensembl
Mir-221-P1a chrX: 45747033-45747096 [-] UCSC Ensembl
Precursor
(pre-Mir +30nt flank)
GCAAGCUGAACAUCCAGGUCUGGGGCAUGAACCUGGCAUACAAUGUAGAUUUCUGUGUUCGUUAGGCAACAGCUACAUUGUCUGCUGGGUUUCAGGCUACCUGGAAACAUGUUCUCCAUUGGC
Get precursor sequence
Structure
        10        20           30        40        50        60  
GCAAGCUGAACAUCCAGG  UG  --  A  -|   UG   U         AUUU    GUUCG 
                  UC  GG  GC UG AACC  GCA ACAAUGUAG    CUGU     U
                  AG  CC  CG AC UUGG  CGU UGUUACAUC    GACA     U
CGGUUACCUCUUGUACAA  GU  AU  G  U^   GU   C         ----    ACGGA 
 120       110       100        90        80            70
Deep sequencing
Go to detailed chart
CommentThe MIR-219 family shows substantial variation of arm-usage and is currently, across all species, considered a co-mature.
3' NTU No
MotifsNo
Tissue expression
-   +
Ad Ar Bl Bo Bo Bo Bo Bo Br Br Br Br Br Br Br Br Br Br Br Es Ga He He He He He Ki Li Lu Ly Mu Ne Pa Pl Pl Sk Sp Sp St Su Te Th To Tr Ve
Mature sequence

Hsa-Mir-221-P2a_5p
mirBase accessionMIMAT0004568
Sequence 
0- ACCUGGCAUACAAUGUAGAUUUCUGU -26
Get sequence
Proposed targets microrna.org: MIMAT0004568
TargetScanVert: hsa-miR-221-5p
TargetMiner: hsa-miR-221-5p
miRDB: MIMAT0004568
Co-mature sequence

Hsa-Mir-221-P2a_3p
mirBase accessionMIMAT0000278
Sequence 
40- AGCUACAUUGUCUGCUGGGUUUC -63
Get sequence
Proposed targets microrna.org: MIMAT0000278
TargetScanVert: hsa-miR-221-3p
TargetMiner: hsa-miR-221-3p
miRDB: MIMAT0000278